Article
Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2012
Wang Chao, Yu Cong, Ye Fei, Wei Zhiyi, Zhang Mingjie
Abstract excerpt
Ankyrin-R/B/G (encoded by ANK1/2/3, respectively) are a family of very large scaffold proteins capable of anchoring numerous receptors and ion channels to specific, spectrin-containing membrane micro-domains. Hereditary mutations of ankyrins are known to be associated with diseases including spherocytosis, cardiac arrhythmia, and bipolar disorder in humans, although the underlying molecular bases are poorly...
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