Article
HCV genetic variability: from quasispecies evolution to genotype classification.
Future microbiology - 1 Apr 2009
Argentini Claudio, Genovese Domenico, Dettori Stefano, Rapicetta Maria
Abstract excerpt
HCV is a ssRNA virus belonging to the Flaviviruses and is found worldwide worldwide in humans. Following primary infection, persistent infection develops in more than 85% of cases, which in up to 30% of cases, may progress to liver disease, cirrhosis and hepatocellular carcinoma. The virus presents a high degree of genetic variability owing to the combination of a lack of proofreading by the RNA-dependent RNA...
Topics
- Adaptation, Biological
- Antiviral Agents
- Drug Resistance, Viral
- Evolution, Molecular
- Genetic Heterogeneity
- Genome, Viral
- Genotype
- Geography
- Hepacivirus
- Hepatitis C, Chronic
- Humans