Article
Clinical significance of hepatitis C virus genotypes and quasispecies.
Seminars in liver disease - 1 Jan 2000
Farci P, Purcell R H
Abstract excerpt
Hepatitis C virus (HCV) is a major cause of morbidity and mortality worldwide. The infection becomes chronic in about 85% of infected individuals, in the face of a strong humoral and cellular immune response. One of the most important features of HCV is its high degree of genetic variability, which is due to the inherent low fidelity of the viral replication machinery. As a consequence, HCV circulates in vivo as...
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