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Article

Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture.

Journal of neuroscience research - 15 Aug 2009

Minagawa Hirohisa, Gong Jiang-Sheng, Jung Cha-Gyun, Watanabe Atsushi, Lund-Katz Sissel, Phillips Michael C, Saito Hiroyuki, Michikawa Makoto

Abstract excerpt

We determined the molecular mechanisms underlying apolipoprotein E (ApoE)-isoform-dependent lipid efflux from neurons and ApoE-deficient astrocytes in culture. The ability of ApoE3 to induce lipid efflux was 2.5- to 3.9-fold greater than ApoE4. To explore the contributions of the amino- and carboxyl-terminal tertiary structure domains of ApoE to cellular lipid efflux, each domain was studied separately. The...

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Identifiers

PMID: 19326444
DOI: 10.1002/jnr.22073
PMCID: PMC3065888

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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