Article
Apolipoprotein A-I-stimulated apolipoprotein E secretion from human macrophages is independent of cholesterol efflux.
The Journal of biological chemistry - 18 Jun 2004
Kockx Maaike, Rye Kerry-Anne, Gaus Katharina, Quinn Carmel M, Wright Janelle, Sloane Timothy, Sviridov Dimitri, Fu Ying, Sullivan David, Burnett John R, Rust Stephan, Assmann Gerd, Anantharamaiah G M, Palgunachari Mayakonda N, Katz Sissel Lund, Phillips Michael C, Dean Roger T, Jessup Wendy, Kritharides Leonard
Abstract excerpt
Apolipoprotein A-I (apoA-I)-mediated cholesterol efflux involves the binding of apoA-I to the plasma membrane via its C terminus and requires cellular ATP-binding cassette transporter (ABCA1) activity. ApoA-I also stimulates secretion of apolipoprotein E (apoE) from macrophage foam cells, although the mechanism of this process is not understood. In this study, we demonstrate that apoA-I stimulates secretion of...
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