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Article

Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2009

Chew Phyllis, Yuen Derek Y C, Koh Philip, Stefanovic Nada, Febbraio Mark A, Kola Ismail, Cooper Mark E, de Haan Judy B

Abstract excerpt

OBJECTIVE: Recently we showed that lack of the antioxidant enzyme glutathione peroxidase-1 (GPx1) accelerates atherosclerosis and upregulates proatherogenic pathways in diabetic apoE/GPx1-deficient double-knockout mice, thereby establishing GPx1 as an important therapeutic target. In vivo studies now investigate ebselen, a seleno-organic GPx1-mimetic, for its potential to reduce diabetes-associated...

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Identifiers

PMID: 19325139
DOI: 10.1161/ATVBAHA.109.186619

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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