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Article

eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling.

Circulation research - 7 Jul 2006

Elrod John W, Duranski Mark R, Langston Will, Greer James J M, Tao Ling, Dugas Tammy R, Kevil Christopher G, Champion Hunter C, Lefer David J

Abstract excerpt

Previous studies indicate that endothelial nitric oxide synthase (eNOS) function is impaired in diabetes as a result of increased vascular generation of reactive oxygen species. We hypothesized that eNOS gene therapy would augment NO. bioavailability and protect against hepatic ischemia-reperfusion (I-R) injury in type 2 diabetes mellitus. We developed a transgenic (Tg) diabetic mouse in which eNOS is...

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PMID: 16763164
DOI: 10.1161/01.RES.0000231306.03510.77

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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