Article
Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice.
Vascular pharmacology - 1 Sept 2017
Salim Hotimah Masdan, Fukuda Daiju, Higashikuni Yasutomi, Tanaka Kimie, Hirata Yoichiro, Yagi Shusuke, Soeki Takeshi, Shimabukuro Michio, Sata Masataka
Abstract excerpt
BACKGROUND: Dipeptidyl peptidase-4 (DPP-4) inhibitors have various cellular effects that are associated with vascular protection. Here, we examined whether teneligliptin alters the pro-inflammatory phenotype of perivascular adipose tissue (PVAT) and inhibits atherogenesis. METHODS AND RESULTS: Teneligliptin (60mg/kg/day) was administered orally to apolipoprotein-E-deficient (ApoE-/-) mice for 20weeks....
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