Article
CAT25 is a mononucleotide marker to identify HNPCC patients.
The Journal of molecular diagnostics : JMD - 1 May 2009
Bianchi Francesca, Galizia Eva, Catalani Romina, Belvederesi Laura, Ferretti Concetta, Corradini Fabio, Cellerino Riccardo
Abstract excerpt
Mismatch repair mutations are the cause of generalized genomic instability and are particularly evident at microsatellite loci, which is known as microsatellite instability (MSI). MSI is present in 85% to 90% of colorectal cancers and occurs in hereditary non-polyposis colorectal cancer (HNPCC). The National Cancer Institute recommends the "Bethesda panel" for MSI screening. Recently, a novel T(25) mononucleotide...
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