Article
CAT25 defines microsatellite instability in colorectal cancer by high-resolution melting PCR.
British journal of biomedical science - 1 Jul 2020
Sánchez A G, Juaneda I, Eynard H, Basquiera A L, Palazzo E, Calafat P, Palla V, Romagnoli P A, Alvarellos T
Abstract excerpt
BACKGROUND: CAT25 (T25mononucleotide repeat of the Caspase 2 gene), is a promising DNA marker for detecting microsatellite instability (MSI) in colorectal cancer. CAT25 has the potential to be incorporated into the Bethesda panel, a commonly used panel of DNA microsatellites, or replace it in its entirety. We aimed to develop and validate a high-resolution melting-PCR (HRM-PCR) method for CAT25 instability...
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