Article
T25 repeat in the 3' untranslated region of the CASP2 gene: a sensitive and specific marker for microsatellite instability in colorectal cancer.
Cancer research - 15 Sept 2005
Findeisen Peter, Kloor Matthias, Merx Sabine, Sutter Christian, Woerner Stefan M, Dostmann Nicole, Benner Axel, Dondog Bolormaa, Pawlita Michael, Dippold Wolfgang, Wagner Rudolf, Gebert Johannes, von Knebel Doeberitz Magnus
Abstract excerpt
DNA mismatch repair deficiency is observed in about 10% to 15% of all colorectal carcinomas and in up to 90% of hereditary nonpolyposis colorectal cancer (HNPCC) patients. Tumors with mismatch repair defects acquire mutations in short repetitive DNA sequences, a phenomenon termed high-level microsatellite instability (MSI-H). The diagnosis of MSI-H in colon cancer is of increasing relevance, because MSI-H is an...
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