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Article

Hepatitis B virus with the rtL80V/I mutation is associated with a poor response to adefovir dipivoxil therapy.

Liver international : official journal of the International Association for the Study of the Liver - 1 Apr 2009

Lee Yoon-Seon, Chung Young-Hwa, Kim Jeong A, Kim Sung Eun, Shin Jung Woo, Kim Kang Mo, Lim Young-Suk, Park Neung Hwa, Lee Han Chu, Lee Yung Sang, Suh Dong Jin

Abstract excerpt

BACKGROUND/AIMS: Lamivudine (LAM) resistance is frequently associated with various types of genomic changes in hepatitis B virus (HBV)-DNA including YMDD mutations (rtM204V/I). We intended to examine the effects of these genotypic variants on the antiviral efficacy of adefovir dipivoxil (ADV) therapy. METHODS: A total of 97 chronic hepatitis B (CHB) patients with YMDD mutants who had been treated with ADV for >12...

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Identifiers

PMID: 19323782
DOI: 10.1111/j.1478-3231.2008.01882.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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