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Article

Transmembrane Domain Length of Influenza a Virus M2 Does Not Determine Its Non-Lipid Raft Localization.

Viruses - 21 Jan 2026

Manzoor Rashid, Okuya Kosuke, Yoshida Reiko, Miyamoto Hiroko, Takada Ayato

Abstract excerpt

Influenza A virus expresses three envelope proteins, hemagglutinin (HA), neuraminidase (NA), and matrix protein 2 (M2). Of these, HA and NA associate with lipid rafts, whereas M2 remains in the peri-raft region. One reason for the lipid raft association of HA and NA is that they possess longer transmembrane domains (TMDs) (27 and 29 amino acids, respectively) than that of M2 (19 amino acids). Moreover, M2...

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PMID: 41600895
DOI: 10.3390/v18010134
PMCID: PMC12846675

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