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Article

Dimerization and a novel Tax speckled structure localization signal are required for Tax nuclear localization.

Journal of virology - 1 Jun 2009

Fryrear Kimberly A, Durkin Sarah S, Gupta Saurabh K, Tiedebohl Jessica B, Semmes O John

Abstract excerpt

The human T-cell leukemia virus type 1 oncoprotein Tax has pleiotropic activities, a subset of which likely leads to immortalization of T cells. Tax is expressed and known to function in both the cell nucleus and the cytoplasm. Tax has defined nuclear localization (NLS) and nuclear export signals that enable shuttling between the two compartments. In this study, we identified a novel region in Tax that targets...

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Source

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Identifiers

PMID: 19321601
DOI: 10.1128/JVI.00232-09
PMCID: PMC2681966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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