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Article

Human T-cell leukemia virus type 1 Tax shuttles between functionally discrete subcellular targets.

Journal of virology - 1 Mar 2000

Burton M, Upadhyaya C D, Maier B, Hope T J, Semmes O J

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-1) Tax is a nuclear protein with striking pleiotropic functionality. We recently demonstrated that Tax localizes to a multicomponent nuclear speckled structure (Tax speckled structure [TSS]). Here, we examine these structures further and identify a partial overlap of TSS with transcription hot spots. We used a strategy of directed expression via fusion proteins to...

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Identifiers

PMID: 10666266
DOI: 10.1128/jvi.74.5.2351-2364.2000
PMCID: PMC111717

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Source receipt: pubmed, retrieved 7 Sept 2026.

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