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Article

Splicing-dependent restriction of the HBZ gene by Tax underlies biphasic HTLV-1 infection

28 Jul 2025

Abstract excerpt

HTLV-1 is an oncovirus that encodes a transactivator Tax and a regulatory gene HBZ. HTLV-1 early or infectious replication depends on Tax; during HTLV-1 late infection, HBZ plays a crucial role in driving the proliferation of infected cells and maintaining viral persistence. The biphasic replication pattern of HTLV-1 dictated by Tax and HBZ represents a result of viral host adaptation, but how HTLV-1 coordinates...

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PMID: 40720552
DOI: 10.1371/journal.ppat.1013381

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Splicing-dependent restriction of the HBZ gene by Tax underlies biphasic HTLV-1 infectionPMID 40720552Read ↗

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