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Article

Plausibility of stromal initiation of epithelial cancers without a mutation in the epithelium: a computer simulation of morphostats.

BMC cancer - 23 Mar 2009

Baker Stuart G, Soto Ana M, Sonnenschein Carlos, Cappuccio Antonio, Potter John D, Kramer Barnett S

Abstract excerpt

BACKGROUND: There is experimental evidence from animal models favoring the notion that the disruption of interactions between stroma and epithelium plays an important role in the initiation of carcinogenesis. These disrupted interactions are hypothesized to be mediated by molecules, termed morphostats, which diffuse through the tissue to determine cell phenotype and maintain tissue architecture. METHODS: We...

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Identifiers

PMID: 19309499
DOI: 10.1186/1471-2407-9-89
PMCID: PMC2663766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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