Article

Targeting ATP2B1 impairs PI3K/Akt/Fox-O3 signaling and reduces SARS-COV-2 replication <i>in vivo</i>

2022-09-06

Abstract excerpt

ATP2B1 is a known regulator of calcium (Ca 2+ ) cellular export and homeostasis. Diminished levels of extra- or intra-cellular Ca 2+ content have been suggested to block SARS-CoV-2 replication. Here, we demonstrate that a newly nontoxic caloxin-derivative compound (PI-7) inhibits ATP2B1, reduces the extra- and intra-cellular Ca 2+ levels and impairs SARS-CoV-2 replication and propagation (VOCs: Delta and Omicron 2...

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Literature Corpus work: 4eae6a93-a29c-53eb-8bc9-05558b869ca8
DOI: 10.1101/2022.09.02.22279542

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