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Article

Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress.

Molecular cell - 5 Dec 2008

Chami Mounia, Oulès Bénédicte, Szabadkai György, Tacine Rachida, Rizzuto Rosario, Paterlini-Bréchot Patrizia

Abstract excerpt

Among the new players at the endoplasmic reticulum (ER)-mitochondria interface regulating interorganelle calcium signaling, those specifically involved during ER stress are not known at present. We report here that the truncated variant of the sarcoendoplasmic reticulum Ca(2+)-ATPase 1 (S1T) amplifies ER stress through the PERK-eIF2alpha-ATF4-CHOP pathway. S1T, which is localized in the ER-mitochondria...

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Identifiers

PMID: 19061639
DOI: 10.1016/j.molcel.2008.11.014
PMCID: PMC2676567

Genes

ATF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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