Article
Evaluation of the roles of Pol zeta and NHEJ in starvation-associated spontaneous mutagenesis in the yeast Saccharomyces cerevisiae.
Current genetics - 1 Jun 2009
Halas Agnieszka, Baranowska Hanna, Podlaska Agnieszka, Sledziewska-Gojska Ewa
Abstract excerpt
The vast majority of microorganisms live under starvation-associated stress conditions that cause mutagenesis despite the limitation of DNA replication and cell division. In this study, we compared the roles of polymerase zeta (Pol zeta) and non-homologous DNA-end joining (NHEJ) in starvation-associated spontaneous base substitutions and frameshifts, using yeast mutants carrying deletions of REV3 (encoding the...
Topics
- Culture Media
- DNA Repair
- DNA Replication
- DNA-Binding Proteins
- DNA-Directed DNA Polymerase
- Frameshift Mutation
- Lysine
- Mutagenesis
- Mutation
- Point Mutation
- Recombination, Genetic
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Time Factors
- Tryptophan