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Article

Mutator alleles of yeast DNA polymerase zeta.

DNA repair - 1 Dec 2007

Sakamoto Ayako N, Stone Jana E, Kissling Grace E, McCulloch Scott D, Pavlov Youri I, Kunkel Thomas A

Abstract excerpt

The yeast REV3 gene encodes the catalytic subunit of DNA polymerase zeta (pol zeta), a B family polymerase that performs mutagenic DNA synthesis in cells. To probe pol zeta mutagenic functions, we generated six mutator alleles of REV3 with amino acid replacements for Leu979, a highly conserved residue inferred to be at the pol zeta active site. Replacing Leu979 with Gly, Val, Asn, Lys, Met or Phe resulted in...

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Identifiers

PMID: 17715002
DOI: 10.1016/j.dnarep.2007.07.002
PMCID: PMC2128049

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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