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Article

Characterization of Regulatory Elements and Methylation Pattern of the Autoimmune Regulator (AIRE) Promoter

1 May 2003

Abstract excerpt

Defects in the AIRE gene cause a monogenic autoimmune syndrome APECED (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy), which is characterized by loss of self-tolerance to multiple organs. In concordance with its role in immune tolerance, AIRE is most strongly expressed in thymic epithelial cells and in cells of monocytic-dendritic lineage. The AIRE protein has been shown to function as a...

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PMID: 12651856
DOI: 10.1074/jbc.m210437200

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