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Article

Pyrosequencing method for sensitive detection of HBV drug resistance mutations.

Journal of medical virology - 1 Jun 2018

Lee Guan-Huei, Inoue Masafumi, Chong Roxanne Hui-Heng, Toh Jimmy, Wee Sue Yuen, Loh Kah-Sin, Lim Seng-Gee

Abstract excerpt

Hepatitis B (HBV) drug resistance assay is important for guiding therapy after the development of virologic breakthrough for patients receiving nucleoside/-tide analog therapy. However, the existing genotyping tools are either costly or lack sensitivity to detect mixed genotypes, and an improved method of resistant mutation detection is needed. An assay protocol for clinical application using pyrosequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29488627
DOI: 10.1002/jmv.25066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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