Article
A common CD4 gene variant is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers.
The Journal of infectious diseases - 1 May 2009
Oyugi Julius O, Vouriot Françoise C M, Alimonti Judie, Wayne Stephen, Luo Ma, Land Allison M, Ao Zhujun, Yao Xiaojian, Sekaly Rafick P, Elliott Lawrence J, Simonsen J Neil, Ball T Blake, Jaoko Walter, Kimani Joshua, Plummer Francis A, Fowke Keith R
Abstract excerpt
BACKGROUND: It has been predicted that CD4 C868T, a novel CD4 single-nucleotide polymorphism (SNP) that has been found to be highly prevalent among Africans, changes the tertiary structure of CD4, which may alter susceptibility to human immunodeficiency virus (HIV) infection. METHODS: Participants were from a Kenyan cohort and included 87 uninfected and 277 HIV-1-infected individuals. DNA sequencing was used to...
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