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Article

Role of the acidic hirudin-like COOH-terminal amino acid region of factor Va heavy chain in the enhanced function of prothrombinase.

Biochemistry - 29 Jul 2008

Hirbawi Jamila, Bukys Michael A, Barhoover Melissa A, Erdogan Evrim, Kalafatis Michael

Abstract excerpt

Prothrombinase activates prothrombin through initial cleavage at Arg(320) followed by cleavage at Arg(271). This pathway is characterized by the generation of an enzymatically active, transient intermediate, meizothrombin, that has increased chromogenic substrate activity but poor clotting activity. The heavy chain of factor Va contains an acidic region at the COOH terminus (residues 680-709). We have shown that...

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Identifiers

PMID: 18590276
DOI: 10.1021/bi800593k
PMCID: PMC2646660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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