Article
99Tcm-sestamibi as an agent for imaging P-glycoprotein-mediated multi-drug resistance: in vitro and in vivo studies in a rat breast tumour cell line and its doxorubicin-resistant variant.
Nuclear medicine communications - 1 Apr 1995
Ballinger J R, Hua H A, Berry B W, Firby P, Boxen I
Abstract excerpt
Multi-drug resistance mediated by the transmembrane pump P-glycoprotein (Pgp) is an important mechanism of resistance of certain tumours against chemotherapeutic drugs. The myocardial perfusion imaging agent 99Tcm-sestamibi is a substrate for Pgp. Further characterization of 99Tcm-sestamibi has now been carried out in the transplantable rat breast adenocarcinoma cell line, MatB, and its doxorubicin-resistant...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Doxorubicin
- Drug Resistance, Multiple
- Female
- Genetic Variation
- Mammary Neoplasms, Experimental
- Radionuclide Imaging
- Rats
- Technetium Tc 99m Sestamibi