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Article

Role of ABC Transporters in the Chemoresistance of Human Gliomas

29 Jun 2006

Abstract excerpt

Malignant gliomas are frequently chemoresistant and this resistance seems to depend on at least two mechanisms. First, the poor penetration of many anticancer drugs across the blood-brain barrier (BBB), the blood-cerebrospinal fluid barrier (BCSFB) and blood-tumor barrier (BTB), due to their interaction with several ATP-binding cassette (ABC) drug efflux transporters that are overexpressed by the endothelial or...

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PMID: 16918310
DOI: 10.2174/156800906777723930

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