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Article

Association of warfarin dose with genes involved in its action and metabolism

18 Oct 2006

Abstract excerpt

We report an extensive study of variability in genes encoding proteins that are believed to be involved in the action and biotransformation of warfarin. Warfarin is a commonly prescribed anticoagulant that is difficult to use because of the wide interindividual variation in dose requirements, the narrow therapeutic range and the risk of serious bleeding. We genotyped 201 patients for polymorphisms in 29 genes in...

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PMID: 17048007
DOI: 10.1007/s00439-006-0260-8

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