Article
Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis.
PLoS genetics - 1 Mar 2009
Hess David C, Myers Chad L, Huttenhower Curtis, Hibbs Matthew A, Hayes Alicia P, Paw Jadine, Clore John J, Mendoza Rosa M, Luis Bryan San, Nislow Corey, Giaever Guri, Costanzo Michael, Troyanskaya Olga G, Caudy Amy A
Abstract excerpt
Mitochondria are central to many cellular processes including respiration, ion homeostasis, and apoptosis. Using computational predictions combined with traditional quantitative experiments, we have identified 100 proteins whose deficiency alters mitochondrial biogenesis and inheritance in Saccharomyces cerevisiae. In addition, we used computational predictions to perform targeted double-mutant analysis detecting...
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