Article
Lack of effect of Ginkgo biloba on voriconazole pharmacokinetics in Chinese volunteers identified as CYP2C19 poor and extensive metabolizers.
The Annals of pharmacotherapy - 1 Apr 2009
Lei He-Ping, Wang Guo, Wang Lian-Sheng, Ou-yang Dong-sheng, Chen Hao, Li Qing, Zhang Wei, Tan Zhi-Rong, Fan Lan, He Yi-Jing, Zhou Hong-Hao
Abstract excerpt
BACKGROUND: Ginkgo biloba is one of the most popular herbal supplements in the world. The supplement has been shown to induce the enzymatic activity of CYP2C19, the main cytochrome P450 isozyme involved in voriconazole metabolism. Because this enzyme exhibits genetic polymorphism, the inductive effect was expected to be modulated by the CYP2C19 metabolizer status. OBJECTIVE: To examine the possible effects of...
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