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Article

CYP2C19-Guided Voriconazole Therapy: A Precision Medicine Approach to Mitigate Adverse Effects in Japanese Patients.

Clinical and translational science - 1 Aug 2025

Katada Yoshiki, Hira Daiki, Umemura Keisuke, Katsube Yurie, Ishimura Hiroki, Kojima Yusuke, Hirai Machiko, Kajiwara Moto, Sugimoto Mitsuhiro, Endo Hiroki, Cao Junru, Ohta Saki, Kotani Kinuka, Hatazoe Sakiko, Tsuda Masahiro, Nakagawa Shunsaku, Shinohara Koh, Tsuchido Yasuhiro, Nagao Miki, Terada Tomohiro

Abstract excerpt

Voriconazole (VRCZ) is a triazole antifungal agent with a broad antifungal spectrum. It is metabolized by hepatic cytochrome P450 (CYP) isozyme CYP2C19, whose genetic polymorphism causes significant variability in drug efficacy and safety. Poor metabolizer alleles of CYP2C19 are more common in Asian populations, increasing the risk of supratherapeutic VRCZ levels. We have developed a novel nomogram based on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40825683
DOI: 10.1111/cts.70317
PMCID: PMC12360865

Genes

CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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CYP2C19-Guided Voriconazole Therapy: A Precision Medicine Approach to Mitigate Adverse Effects in Japanese Patients.PMID 40825683Read ↗

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