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Article

Pharmacogenetics of steady-state metabolism, pharmacokinetics, and adverse effects of voriconazole in healthy participants.

Drug metabolism and disposition: the biological fate of chemicals - 1 Oct 2025

Wu Yanting Phoebe, Gelal Ayşe, Moon Chisook, Metzger Ingrid F, Lu Jessica B L, Callaghan John T, Skaar Todd C, Desta Zeruesenay

Abstract excerpt

Voriconazole, a broad-spectrum antifungal, exhibits significant interpatient variability in efficacy and safety. This study assessed the influence of genetic and nongenetic factors on its steady-state pharmacokinetics and adverse effects. In vitro studies characterized voriconazole metabolism. An ancillary analysis was conducted on data from a completed trial involving 61 healthy participants who received a...

Read the complete abstract on PubMed

Topics

Humans
Voriconazole
Male
Adult
Female
Antifungal Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Healthy Volunteers

Cytochrome P-450 CYP2C19

Genotype

Young Adult

Middle Aged

Cytochrome P-450 CYP3A

Pharmacogenetics

Source

Open in PubMed Open full text

Identifiers

PMID: 41027046
DOI: 10.1016/j.dmd.2025.100156
PMCID: PMC12818346

Genes

CYP2C19
CYP3A4
CYP2C9
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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