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Article

Effect of CYP2C19 polymorphism on the pharmacokinetics of voriconazole after single and multiple doses in healthy volunteers.

Journal of clinical pharmacology - 1 Feb 2012

Lee SeungHwan, Kim Bo-Hyung, Nam Won-Seok, Yoon Seo Hyun, Cho Joo-Youn, Shin Sang-Goo, Jang In-Jin, Yu Kyung-Sang

Abstract excerpt

The current study assessed the influence of the CYP2C19 genotype on the pharmacokinetics and tolerability of voriconazole after single and multiple oral doses in healthy volunteers. Six subjects for the CYP2C19 homozygous extensive metabolizer (EMs), 6 for heterozygous extensive metabolizer (HEMs), and 6 for poor metabolizer (PMs) were enrolled, and their CYP2C9, CYP3A5, and MDR1 genotypes were analyzed. After a...

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Identifiers

PMID: 21383338
DOI: 10.1177/0091270010395510

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Effect of CYP2C19 polymorphism on the pharmacokinetics of voriconazole after single and multiple doses in healthy volunteers.PMID 21383338Read ↗

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The influence of CYP2C19 polymorphisms on voriconazole trough concentrations: Systematic review and meta-analysis.Semantic proximity Read ↗

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A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles.Semantic proximity Read ↗

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