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Article

The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway.

Developmental biology - 15 Apr 2009

King Ryan S, Maiden Stephanie L, Hawkins Nancy C, Kidd Ambrose R, Kimble Judith, Hardin Jeff, Walston Timothy D

Abstract excerpt

Dishevelleds are modular proteins that lie at the crossroads of divergent Wnt signaling pathways. The DIX domain of dishevelleds modulates a beta-catenin destruction complex, and thereby mediates cell fate decisions through differential activation of Tcf transcription factors. The DEP domain of dishevelleds mediates planar polarity of cells within a sheet through regulation of actin modulators. In Caenorhabditis...

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Identifiers

PMID: 19298786
DOI: 10.1016/j.ydbio.2009.01.017
PMCID: PMC4409331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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