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Article

A common hereditary single-nucleotide polymorphism in the gene of FAS and colorectal cancer survival.

Journal of cellular and molecular medicine - 1 Sept 2009

Hofmann Guenter, Langsenlehner Uwe, Langsenlehner Tanja, Yazdani-Biuki Babak, Clar Heimo, Gerger Armin, Fuerst Florentine, Samonigg Hellmut, Krippl Peter, Renner Wilfried

Abstract excerpt

Apoptosis plays an important role in embryogenesis, autoimmunity and tumourigenesis. Cell surface death receptors such as TNFRSF6 (FAS) confer a major apoptotic effect. A single-nucleotide polymorphism in the FAS promoter gene, -670A/G, modulates apoptotic signalling and has been related to susceptibility and progression of a variety of cancers. The present study aimed to evaluate the role of this polymorphism...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19298528
DOI: 10.1111/j.1582-4934.2009.00720.x
PMCID: PMC4516518

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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