Article
Fas -670A/G (rs1800682) polymorphism and digestive cancer risk in Asians: a meta-analysis.
Genetic testing and molecular biomarkers - 1 Jul 2014
Yuan Hai-Peng, Liu Qing-Dong, Li Gai-Qin, Cong Yan-Qun
Abstract excerpt
OBJECTIVES: Tumorigenesis is a multistep process that begins with the abrogation of normal controls of apoptosis and cell proliferation, and the Fas receptor-ligand system is a key regulator of apoptosis. The Fas -670 A/G single-nucleotide polymorphism (SNP) has been demonstrated to affect the expression of the Fas gene by altering the transcriptional activity in this gene's promoter. However, the association...
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