Article
Association between the FAS rs2234767G/A polymorphism and cancer risk: a systematic review and meta-analysis.
DNA and cell biology - 1 May 2014
Wang Xin, Xing Guo-Hong, Fan Chang-Chun
Abstract excerpt
Abnormal regulation of apoptosis can lead to carcinogenesis. Single nucleotide polymorphisms in apoptotic genes have been associated with cancer risk, such as the FAS rs2234767G/A polymorphism, which alters transcription of the FAS promoter. Downregulation of FAS, with resultant cellular resistance to death signals, has been found in many cancers. However, the association between the FAS rs2234767G/A polymorphism...
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