Article
The pleckstrin homology domain of the Arf6-specific exchange factor EFA6 localizes to the plasma membrane by interacting with phosphatidylinositol 4,5-bisphosphate and F-actin.
The Journal of biological chemistry - 11 Jul 2008
Macia Eric, Partisani Mariagrazia, Favard Cyril, Mortier Eva, Zimmermann Pascale, Carlier Marie-France, Gounon Pierre, Luton Frédéric, Franco Michel
Abstract excerpt
The Arf6-specific exchange factor EFA6 coordinates membrane trafficking with actin cytoskeleton remodeling. It localizes to the plasma membrane where it catalyzes Arf6 activation and induces the formation of actin-based membrane ruffles. We have shown previously that the pleckstrin homology (PH) domain of EFA6 was responsible for its membrane localization. In this study we looked for the partners of the PH domain...
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