Article
Effect of Fabp1/Scp-2/Scp-x Ablation on Whole Body and Hepatic Phenotype of Phytol-Fed Male Mice.
Lipids - 1 May 2017
Landrock Danilo, Milligan Sherrelle, Martin Gregory G, McIntosh Avery L, Landrock Kerstin K, Schroeder Friedhelm, Kier Ann B
Abstract excerpt
Liver fatty acid binding protein (Fabp1) and sterol carrier protein-2/sterol carrier protein-x (SCP-2/SCP-x) genes encode proteins that enhance hepatic uptake, cytosolic transport, and peroxisomal oxidation of toxic branched-chain fatty acids derived from dietary phytol. Since male wild-type (WT) mice express markedly higher levels of these proteins than females, the impact of ablating both genes (TKO) was...
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