Article
Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice.
Journal of lipid research - 1 Nov 2006
Wang Wen-Jun, Baez Juan M, Maurer Rie, Dansky Hayes M, Cohen David E
Abstract excerpt
Phosphatidylcholine transfer protein (PC-TP) is a cytosolic phospholipid binding protein and a member of the steroidogenic acute regulatory-related transfer domain superfamily. Its tissue distribution includes liver and macrophages. PC-TP regulates hepatic lipid metabolism, and its absence in cholesterol-loaded macrophages is associated with reduced ATP binding cassette transporter A1-mediated lipid efflux and...
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