Article
Involvement of Fc(epsilon)R1beta gene polymorphisms in susceptibility to atopy in Korean children with asthma.
European journal of pediatrics - 1 Dec 2009
Kim Eun Soo, Kim Seung-Hyun, Kim Kyung Won, Park Hae-Sim, Shin Eun Soon, Lee Jong Eun, Sohn Myung Hyun, Kim Kyu-Earn
Abstract excerpt
INTRODUCTION: IgE-dependent activation of mast cells and basophils through the high-affinity IgE receptor (Fc(epsilon)R1) is involved in the pathogenesis of allergen-induced immune responsiveness in atopic disease including bronchial asthma. MATERIALS AND METHODS: We genotyped 650 children for allelic determinants at two polymorphic sites, -109T/C and E237G, in the Fc(epsilon)R1beta gene by SNP-IT assays using...
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