Article
ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jun 2004
Lee J H, Park H-S, Park S W, Jang A S, Uh S T, Rhim T, Park C-S, Hong S-J, Holgate S T, Holloway J W, Shin H D
Abstract excerpt
BACKGROUND: A disintegrin and metalloprotease 33 (ADAM33) is expressed in the lung by fibroblasts and bronchial smooth muscle cells. Given its structure and cellular provenance, ADAM33 may be associated with airway remodelling and bronchial hyper-responsiveness. Single nucleotide polymorphisms (SNPs) and haplotypes of the ADAM33 gene have previously been associated with asthma susceptibility in the Caucasian...
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