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Article

Functionally distinct isoforms of Cik1 are differentially regulated by APC/C-mediated proteolysis.

Molecular cell - 13 Mar 2009

Benanti Jennifer A, Matyskiela Mary E, Morgan David O, Toczyski David P

Abstract excerpt

Cik1, in association with the kinesin Kar3, controls both the mitotic spindle and nuclear fusion during mating. Here, we show that there are two Cik1 isoforms, and that the mitotic form includes an N-terminal domain required for ubiquitination by the Anaphase-Promoting Complex/Cyclosome (APC/C). During vegetative growth, Cik1 is expressed during mitosis and regulates the mitotic spindle, allowing for accurate...

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Source

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Identifiers

PMID: 19285942
DOI: 10.1016/j.molcel.2009.01.032
PMCID: PMC2883288

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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