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Article

Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation.

Molecular biology of the cell - 1 Jun 2004

Ohi Ryoma, Sapra Tanuj, Howard Jonathan, Mitchison Timothy J

Abstract excerpt

The KinI kinesin MCAK is a microtubule depolymerase important for governing spindle microtubule dynamics during chromosome segregation. The dynamic nature of spindle assembly and chromosome-microtubule interactions suggest that mechanisms must exist that modulate the activity of MCAK, both spatially and temporally. In Xenopus extracts, MCAK associates with and is stimulated by the inner centromere protein ICIS....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15064354
DOI: 10.1091/mbc.e04-02-0082
PMCID: PMC420112

Genes

INCENP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation.PMID 15064354Read ↗

Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.Semantic proximity Read ↗

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Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK).Semantic proximity Read ↗

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