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Article

Ozone, oxidant defense genes, and risk of asthma during adolescence.

American journal of respiratory and critical care medicine - 15 Feb 2008

Islam Talat, McConnell Rob, Gauderman W James, Avol Ed, Peters John M, Gilliland Frank D

Abstract excerpt

RATIONALE: Although oxidative stress is a cardinal feature of asthma, the roles of oxidant air pollutants and antioxidant genes heme oxygenase 1 (HMOX-1), catalase (CAT), and manganese superoxide dismutase (MNSOD) in asthma pathogenesis have yet to be determined. OBJECTIVES: We hypothesized that the functional polymorphisms of HMOX-1 ([GT](n) repeat), CAT (-262C>T -844C>T), and MNSOD (Ala-9Val) are associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18048809
DOI: 10.1164/rccm.200706-863OC
PMCID: PMC2258440

Genes

CAT

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