Article
ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts.
American journal of respiratory and critical care medicine - 1 Oct 2008
Litonjua Augusto A, Lasky-Su Jessica, Schneiter Kady, Tantisira Kelan G, Lazarus Ross, Klanderman Barbara, Lima John J, Irvin Charles G, Peters Stephen P, Hanrahan John P, Liggett Stephen B, Hawkins Gregory A, Meyers Deborah A, Bleecker Eugene R, Lange Christoph, Weiss Scott T
Abstract excerpt
RATIONALE: Inhaled beta-agonists are one of the most widely used classes of drugs for the treatment of asthma. However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients. OBJECTIVES: To screen variants in candidate genes in the steroid and beta-adrenergic...
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