Article
Regulatory haplotypes in ARG1 are associated with altered bronchodilator response.
American journal of respiratory and critical care medicine - 15 Feb 2011
Duan Qing Ling, Gaume Brigitte R, Hawkins Gregory A, Himes Blanca E, Bleecker Eugene R, Klanderman Barbara, Irvin Charles G, Peters Stephen P, Meyers Deborah A, Hanrahan John P, Lima John J, Litonjua Augusto A, Tantisira Kelan G, Liggett Stephen B
Abstract excerpt
RATIONALE: β₂-agonists, the most common treatment for asthma, have a wide interindividual variability in response, which is partially attributed to genetic factors. We previously identified single nucleotide polymorphisms in the arginase 1 (ARG1) gene, which are associated with β₂-agonist bronchodilator response (BDR). OBJECTIVES: To identify cis-acting haplotypes in the ARG1 locus that are associated with BDR in...
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