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Article

Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition.

Kidney international - 1 Jun 2009

Sun Shiren, Ning Xiaoxuan, Zhang Yanqi, Lu Yuanyuan, Nie Yongzhan, Han Shuang, Liu Lili, Du Rui, Xia Lin, He Lijie, Fan Daiming

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT) induced by chronic hypoxia is one of the critical causes of renal fibrosis. Twist, a basic helix-loop-helix transcription factor, is believed to be important in promoting EMT. We found that the expression of Twist was increased in human tubule cell lines (HK-2 and HKC) grown under hypoxic conditions. This was accompanied by reduced expression of the epithelial markers...

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Source

Identifiers

PMID: 19279556
DOI: 10.1038/ki.2009.62

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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