Article
miR-363 induces transdifferentiation of human kidney tubular cells to mesenchymal phenotype.
Clinical and experimental nephrology - 1 Jun 2016
Morizane Ryuji, Fujii Shizuka, Monkawa Toshiaki, Hiratsuka Ken, Yamaguchi Shintaro, Homma Koichiro, Itoh Hiroshi
Abstract excerpt
BACKGROUND: microRNAs (miRNAs) are non-coding small RNAs that regulate embryonic development, cell differentiation and pathological processes via interaction with mRNA. Epithelial-mesenchymal transition (EMT) is pathological process that involves in a variety of diseases such as cancer or fibrosis. METHODS: In this study, we identified miR-363 as a potent inducer of EMT by microarray analysis in human kidney...
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