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Article

Twist: a new link from hypoxia to fibrosis.

Kidney international - 1 Jun 2009

Bechtel Wibke, Zeisberg Michael

Abstract excerpt

Sun et al. demonstrate that hypoxia causes epithelial-to-mesenchymal transition by activating Twist, a transcription factor known to mediate both acquisition of a mesenchymal phenotype and resistance to apoptosis in cancer cells. This study provides clues as to how hypoxia and transforming growth factor-beta can collaborate to drive renal fibrogenesis.

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19483748
DOI: 10.1038/ki.2009.102

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Twist: a new link from hypoxia to fibrosis.PMID 19483748Read ↗

Emerging role of Twist1 in fibrotic diseasesSemantic proximity Read ↗

Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition.Semantic proximity Read ↗

TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and developmentSemantic proximity Read ↗

A twist tale of cancer metastasis and tumor angiogenesis.Semantic proximity Read ↗

Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other DiseasesSemantic proximity Read ↗

Direct regulation of TWIST by HIF-1alpha promotes metastasis.Semantic proximity Read ↗

HIF-1α Mediates Tumor Hypoxia to Confer a Perpetual Mesenchymal Phenotype for Malignant ProgressionA presentation from the Keystone Symposium on Epithelial Plasticity and Epithelial-to-Mesenchymal Transition, Vancouver, British Columbia, Canada, 21 to 26 January 2011.Semantic proximity Read ↗

AKT-ions with a TWIST between EMT and MET.Semantic proximity Read ↗

Gene Expression Profiling of Pulmonary Fibrosis Identifies Twist1 as an Antiapoptotic Molecular “Rectifier” of Growth Factor SignalingSemantic proximity Read ↗

Twist2 promotes kidney cancer cell proliferation and invasion by regulating ITGA6 and CD44 expression in the ECM-receptor interaction pathwaySemantic proximity Read ↗

Epithelial–Mesenchymal Transition: From Molecular Mechanisms, Redox Regulation to Implications in Human Health and DiseaseSemantic proximity Read ↗

Regulation of Cancer Cell Survival, Migration, and Invasion by Twist: AKT2 Comes to InterplaySemantic proximity Read ↗

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